Journal article
Evaluating whole genome sequence data from the genetic absence epilepsy rat from strasbourg and its related non-epileptic strain
PM Casillas-Espinosa, KL Powell, M Zhu, CR Campbell, JM Maia, Z Ren, NC Jones, TJ O'Brien, S Petrovski
Plos One | Published : 2017
Abstract
Objective The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are an inbreed Wistar rat strain widely used as a model of genetic generalised epilepsy with absence seizures. As in humans, the genetic architecture that results in genetic generalized epilepsy in GAERS is poorly understood. Here we present the strain-specific variants found among the epileptic GAERS and their related Non-Epileptic Control (NEC) strain. The GAERS and NEC represent a powerful opportunity to identify neurobiological factors that are associated with the genetic generalised epilepsy phenotype. Methods We performed whole genome sequencing on adult epileptic GAERS and adult NEC rats, a strain derived from the sam..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Pablo M. Casillas-Espinosa was funded by a Melbourne Research Scholarship. Work for this project was supported in part by a NH&MRC Project Grant to Terence OBrien and Kim Powell and a R.D Wright Career Development Fellowship (1126877) to SP. The current affiliation of JMM, BD technologies, provides support in the form of salaries for JMM, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.